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Literature summary extracted from

  • Duncan, R.C.; Wijeyewickrema, L.C.; Pike, R.N.
    The initiating proteases of the complement system: controlling the cleavage (2008), Biochimie, 90, 387-395.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.41 C1-inhibitor regulates the classical and the lectin complement pathway inhibiting complement components C1r and C1s, and MASP-2, factor XIa, Factor XIIa, and plasma kallikrein, mechanism, overview Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.21.41 Ca2+ binding of four Ca2+ per enzyme dimer Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.41 88000
-
 x * 88000, C1r zymogen, domain structure, overview Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.41 complement component C1s + H2O Homo sapiens the enzyme is part of the Ca2+-dependent tetramer C1s-C1r-C1r-C1s, termed as C1 complex, which is associated with the recognition molecule C1q, autoactivation of C1r, which then activates proenzyme C1s through cleavage at an Arg-Ile bond in the serine domain, C1r is active in the classical pathway of the complement system activated complement component C1s + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.41 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.21.41 glycoprotein
-
 Homo sapiens
3.4.21.41 proteolytic modification autoactivation of C1r as part of the C1 complex Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.41 complement component C1s + H2O the enzyme is part of the Ca2+-dependent tetramer C1s-C1r-C1r-C1s, termed as C1 complex, which is associated with the recognition molecule C1q, autoactivation of C1r, which then activates proenzyme C1s through cleavage at an Arg-Ile bond in the serine domain, C1r is active in the classical pathway of the complement system Homo sapiens activated complement component C1s + ?
-
 ?
3.4.21.41 complement component C1s + H2O C1r cleaves proenzyme C1s at an Arg-Ile bond in the serine domain Homo sapiens activated complement component C1s + ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.21.41 ? x * 88000, C1r zymogen, domain structure, overview Homo sapiens
3.4.21.41 More C1 complex structure Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.21.41 C1r
-
 Homo sapiens